Nippon Shokakibyo Gakkai Zasshi
Online ISSN : 1349-7693
Print ISSN : 0446-6586
Clinical studies on the effect of sodium dehydrocholate upon biliary excretion and urinary excretion of sulfobromophthalein
Kinya Murata
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1969 Volume 66 Issue 9 Pages 988-991

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Abstract

The effects of sodium dehydrocholate (DHC) upon the maximal transport of BSP into bile (biliary BSP-Tm), relative hepatic storage of BSP (BSP-S) and urinary excretion of BSP were estimated in normal persons and patients with liver disease.
The biliary BSP-Tm and BSP-S were estimated according to the technique which was described by Adams and his co-workers (1966). The 24 hours' urinary excretion rate of BSP to the total infused BSP during the experimental period of the estimation of BSP-Tm was determined. Sodium dehydrocholate was infused intravenously at a constant rate of 10 to 15mg per minute during the experimental period of the estimation of BSP-Tm. The experiment with DHC was carried out 7 days before or after the control experiment.
The following results were obtained.
1) The BSP-Tm and BSP-S were generally decreased and the urinary excretion of BSP was increased in the patients with liver disease.
2) The administration of DHC resulted in a slight increase of the BSP-Tm, a distinct decrease of the BSP-S, an increase of urine output and an increase of the urinary excretion of BSP especially among the patients with liver disease.

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© The Japanese Society of Gastroenterology
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