Effect of Various Kinds of Diet on the Enzyme Secretion of the Pancreas

An Experimental Study with the Use of Rats

Abstract

Rats of Wistar strain weighing about 50g on an average were used throughout the present experiments. The rats were divided into 3 groups and they were fed on highprotein-highfat, high carbohydrate and low protein diets, respectively. On that special diets, rats fed for 4 months were classified as long-term feeding group. Otherweise, they, first fed on balanced diet for 4 months and then fed on that special diets for one week, were classified as short-term one.
We analyzed the enzyme concentration obtained from duodenal collection pre-and postpancreozymin and secretin stimulation. From this analysis, an "adaptation" reactive pattern of the enzyme secretion to the main constituent of the diet had been found for amylase and trypsin, which were significantly increased when rats, of either longterm or short-term feeding group, were fed on highcarbohydrate and high protein diet. Lipase was not influenced by the high-fat diet.
To a certain extent, the results mentioned above seem to explain one of the reasons why the difference in the clinical features of chronic pancreatitis between Japanese and Westerners may be referred to the varied pancreatic tissue reaction based on the different dietary habits.