1970 年 67 巻 2 号 p. 122-141
Ioslated homo- or hetero-logous liver perfusion is being used in the treatment of hepatic failure which may provide temporary support for the patients. The present study is subjected to decide an optimal condition for liver perfusion and a liver function under cooled preservation using laboratory animals, and resulted in the followings:
1) From these data of liver function tests, rate of bile outflow, liver outflow block and liver oxygen consumption, two systemic perfusions of portal vein and hepatic artery are need to perfuse the liver with volume rate at 0.5-1.0ml. per gram of liver per minute.
2) Perfused liver to preserve under 4 degree C. showed no remarkable changes on histological and functional examinations within six hours.
3) Perfusions of fresh liver and cooled preserved liver did well and resulted in successful for the treatment of experimental hepatic failure. This method could improve the general condition of the animals and not find any functional differences between fresh liver and cooled preserved liver.