1970 Volume 67 Issue 2 Pages 91-98
Clinical and pathological findings were reported on three cases of ulcerative colitis. On microscopic examination, cryptitis and cryptabscess were observed in early lesion of the disease, and subsequent formation of ulcer was seen, having granulation tissue with numerous plasma cells and abundant vascularization in the base of it. Regeneration of mucous membrane, proliferation of edematous connective tissue and formation of pseudopolyposis ensued. These pathological processes were characteristic of this disease, and always repeatedly occurred. There were neither vasculitis as a cause of ulcerative colitis which was described by Warren and Sommers et al. nor atrophic change of mucous membrane described by Matsunaga et al. in our three cases.