肝の排泄機構に関する研究

BSP排泄に及ぼすビリルビンの影響

抄録

Rat experiments were undertaken to examine the alterations of steps involved in the transfer of BSP from blood to bile following the intravenous administration of bilirubin.
1) Biliary excretion of BSP and bile output were decreased by the administration of bilirubin.
2) Biliary BSP-Tm (transport maximum) was unchanged by the administration of bilirubin.
3) A decrease of BSP storage in the liver was demonstrated by the administration of bilirubin, which suggests a decrease of hepatic uptake of BSP from blood stream.
4) An acceleration of BSP-glutathione conjugating enzyme activity was noted by the addition of bilirubin in vitro, but the conjugation rate of the biliary BSP was somewhat decreased by the intravenous administration of bilirubin in vivo.
5) Inhibition of BSP-binding affinity of serum albumin and release of BSP from BSP-bound serum was not demonstrated by the addition of bilirubin in vitro.
6) The above facts gussest that the most important factor to decrease biliary excretion of BSP following the intravenous administration of bilirubin may be a decrease of hepaticuptake of BSP from blood stream.