Nippon Shokakibyo Gakkai Zasshi
Online ISSN : 1349-7693
Print ISSN : 0446-6586
The Studies on the Inhitory Activity of Secretin and Gastrone upon Gastrin Ulcerogenesis
Kose SEGAWA
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JOURNAL FREE ACCESS

1972 Volume 69 Issue 5 Pages 474-490

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Abstract

The gastro-duodenal ulcer was produced in rat through the intravenous administration of gastrin-tetrapeptide. Its ulcerogenesity was decreased by the gastro-intestinal hormones, secretin and gastrone-like substance. To disclose the mechanism of gastrin-ulcerogenesis and the inhibitory mechanism by secretin and gastrone, the activity of gastrin and the effect of secretin and gastrone were studied as regard to acid-output, pepsin secretion, duodenal motility and parietal cell formation.
The secretin was extracted from the hog duodenum at Eisai, Ltd.(Tokyo). The gastrone was the glyco-peptide extracted from the whale at Nissui Seiyaku, Ltd., (Tokyo).
The followings are the results:
1) The duodenal ulcer was produced at the rate of 60% by intravenous administration of gastrin (100γ/kg-h.) for 12 hours. The admixture of secretin (8 U/kg-h.) or gastrone (960γ/kg-h.) lowered the ulcerogenesity to the rate of 20%.
2) In the group administered with gastrin the mean acid out-put for 6 hours amounted to 0.532±0.0708 mEq; 0.1082±0.0148 mEq in gastrin and secretin; 0.0968±0.0189 mEq in gastrin and gastrone. The number of each experiment was 6.
3) The peptic output for 6 hours amounted to 13.69±59 tyrosine mg in the group administered with gastrin; 16.82±1.09 tyr. mg in gastrin and secretin; 14.05±1.22 tyr. mg in gastrin and gastrone and 7.04±0.60 tyr. mg in control group. The statistically significant difference exists between gastrin group and control group; gastrin group and‘gastin +secretin’group.
4) The duodenal motility was activated slightly by gastrin compared with saline. The gastrin activity was inhibited by secretin and gastrone above mentioned. The inhibitory activity of gastrone was stronger than secretin.
5) The number of the parietal cell and the height of mucous membrane at the fundic area of rats, which were administered with gastrin solved in 16.6% gelatin for 30 days, increased as compared with control group administered with 16.6% gelatin for the same period. This activity was, also, reduced by secretin (8U) or gastrone (960γ) similarly.
From the data above mentioned the author supposes that the gastro-intestinal hormones may play the important role in the ulcerogenesis.

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© The Japanese Society of Gastroenterology
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