Role of the Gastric Antrum Retained in Pylorus-preserving Gastrectomy in Gastric Secretion

Abstract

This experiment is designed to study the role of the distal 1.5cm of antral cuff retained in pylorus-preserving gastrectomy. Heidenhain pouch secretions in response to meal were collected and assayed for volume and acidity. After the pylorus-preserving gastrectomy, the mean volume of five hour pouch secretion was 12.1ml. The reduction in secretory volume was 57.4 per cent. The mean acid concentration fell to a value of 75.1mEg/l, a reduction of 33.8 per cent. The mean acid output fell to a value of 0.92mEg, a reduction of 71.7 per cent. But, gastric secretion of the dog that showed gastric stasis was not sufficiently reduced after the operation. In temporal relationships between the stimulus and secretory response, gastric secretory pattern after gastrectomy was similar to that of the control.
It is suggested that acid output in pylorus-preserving gastrectomy decreases adequately, but the 1.5cm of antral cuff is able to be stimulated strongly to release gastrin by mechanical distention.