An Experimental Study on Gastric Ulcer

microcirculatory changes of gastric mucosa

Abstract

Several ulcerogenic factors were tried to rats and the vascular changes of the microcirculation of the stomach were observed superficially and from the lateral side untill the ulcerformation started.
1) In the serotonin administered rats, it was observed that the collecting venules constricted in the middle to deeper layer of the mucosa and superficial capillaries dilated secondarily and then ulcerformation occurred.
2) In the reserpine treated rats, two types of change appeared; i) the quite same process to that of the serotonin received rats and ii) influence of gastric juice, that is, the histological defect from superficial side, was added to that process 4 hours after injection.
3) In the HCl intragastrically perfused rats, extensive superficial capillary dilatation was observed and then hemorrhage and ulcerformation followed.
4) In the gastrin treated rats, it was observed that the mucosal vascular changes occurred secondarily as a result of the hypersecretion of the gastric juice and then the ulcer was formed.
5) In the restraint rats, the severe constriction of the terminal arterioles and the capillary enlargement of the peripheral portion were observed in the anterior and posterior wall of the fundic area and then hemorrhage and ulcerformation occurred.