Abstract
In spite of numerous reports of secondary lactose intolerance in post-gastrectomy, only a few reports have been found regarding changes of sucrose absorption after resection of gastrointestinal tract.
Since the sucrose is contained more in quantity than the lactose in ordinary adult food and the fructose, one of the component of sucrose, is the non-active transported monosaccharide in the intestine, the sucrose absorption after resection of the gastrointestinal tract would reveal one of the most important changes of the intestinal function.
In this paper the author studied the oral tolerance test of sucrose (STT) and glucosefructose (GFTT) and intestinal sucrase activity in dogs with gastrectomy or massive small bowel resection.
The following results were obtained.
1) The sucrase activity of the upper small intestine was depressed to about 75% of the preoperative status in gastrectomized dogs with Billroth I.
2) The intestinal sucrase activity of the oral portion and anal portion at anastomotic site corresponded to each activity of the preoperative upper small intestine and lower small intestine, revealing no compensatory changes of sucarse activity of the remnant of the small intestine in dogs with massive small bowel resection. So, the dogs with massive small bowel resection showed the absolute intestinal sucrase deficiency as a whole on account of loss of resected bowel activity.
3) In spite of elevated fructose absorption curve in both STT and GFTT, the decreased fructose absorption ratio estimated from STT and GFTT fructose curve showed the relative sucrose intolerance in gastrectomized dogs.
4) In addition to depressed fructose absorption curve in both STT and GFTT the decreased fructose absorption ratio revealed not only absolute sucrose intolerance but also relative intolerance in dogs with massive small bowel resection.
Therefore, the dogs with gastrectomy or massive small bowel resection became of sucrase deficiency with each characteristic pattern, leaving the different sucrose intolerance in both gastrectomy or massive small bowel resection each other.
