Nippon Shokakibyo Gakkai Zasshi
Online ISSN : 1349-7693
Print ISSN : 0446-6586
Follow-up Study on Upper Gastrointestinal Lesions in Familial Polyposis of the Colon
Keiichi OHSATOHideaki ITOHSeiyo IKEDAMasaya NISHIMURATsuneyoshi YAOMitsuo IIDAHidenobu WATANABE
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1975 Volume 72 Issue 2 Pages 141-148

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Abstract

Careful upper gastrointestinal survey including gastrointestinal X-ray series, gastric and/or duodenal fiberscopy, and endoscopic biopsy was carried out for associated lesions in the upper gastrointestinal tract in 11 cases with familial polyposis during the past 11 years. These examinations revealed the presence of polyp(s) and/or carcinomas of the stomach and/ or duodenum in nine or 82 per cent. In 8 of the 9 cases polyp(s) were noted. The polyps were present in 5 cases in both stomach and duodenum including one case with concomitant presence of multiple gastric adenocarcinomas. Two cases had polyps in the duodenum and one in the stomach. Histological examination revealed all polyps to be adenomas except for one with multiple hamartomatous polyposis of the stomach. In remaining one case, multiple gastric carcinomas composed of signet-ring cells without presence of polyp were found to be present. Follow-up study revealed the possible malignant change of polyp in one case. The rather frequent coexistence of gastroduodenal lesions with familial polyposis and their malignant potential indicate the importance of routine follow-up study on the upper gastrointestinal tract in dealing with familial polyposis of the colon.

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© The Japanese Society of Gastroenterology
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