Studies on the Healing Process of Gastric Ulcer

Statistical Examination of Influential Factors on Healing and Prediction of Healing time

Abstract

The factors to influence the healing of gastric ulcer were examined by Kruskal-Wallis test. In patients with single, round ulcer in which healing process was obvious were selected as the subjects, and 20 factors were examined. Seven factors were piked up by kruskal-Wallis test, and then the contribution of each factor to the healing of gastric ulcer was evaluated by Hayashi's theory of quantification. As the results, it was concluded that the 1st class factors to influence healing of gastric ulcer were healing stage of ulcer, and size of ulcer nische. The 2nd class factors were convergence of folds, marginal swelling, and duration of epigastric complaints. Shortening of the lesser curvature and location of ulcers were also suspected as the 2nd factors.
The subjects were classified into the following groups by healing time: the 1st group (within 60 days), the 2nd group (61 to 90 days) and the 3rd group (more than 90 days). For each group, cumurative-distribution polygon was made. Using data of the 1st examination, the 1st group was discriminated from the 2nd and 3rd groups with error of 22%. It was presumed that discrimination one month after the therapy can be done between the 2nd and 3rd group with error of 6% and it can be done between the 1st and 2nd group with error of 32%, using the reducing rate of ulcer nische one month after the therapy with data of the 1st examination.