Serum Gastrin Levels of Upper Gastrointestinal Diseases

Abstract

Serum gastrin levels in patients with upper gastrointestinal diseases were measured with CIS-gastrin radioimmunoassay kit. All subjects roled out diabetic mellitus, liver cirrhosis and renal disorder, had the upper GI series and endoscopic examination beforehand.
In the basal condition there were 27±15pg/ml in normal subjects, 57±41pg/ml in patients with single gastric ulcer, 71±44pg/ml in duodenal ulcer, 81±76pg/ml in early gastric cancer and 125±95pg/ml in advanced gastric cancer.
Basal serum gastrin level increased in proportion to atrophy of gastric mucosa but reversely decreased in severe atrophy. There was no definite tendency between age and the basal serum gastrin level in subjects younger than 60 years old, but descending tendency in ones older than 61 years old.
After sodium bicarbonate and propantheline bromide were given, serum gastrin level increased and the rate of serum gastrin level to the basal showed a peak 60 minutes after the drug administration in duodenal ulcer. The peak in normal controls or gastric ulce appeared earlier than that in duodenal ulcer.
By secretin injection, serum gastrin level decreased and the rate of serum gastrin level to the basal took the lowest value 120 minutes after secretin injection in duodenal ulcer, in which the peak came slower than in normal subjects or gastric ulcer.