Clinical and Experimental Studies on the Etiology of Peptic Ulcer

Abstract

The etiology of peptic ulcer was studied separately from the view point of acid, pepsin and mucus. On the series of experimental studies the peptic ulcer was made by the perfusion method originally devised by the author in rats and the effect of acid, pepsin and mucus on the ulcerogenesis was separately examined with the factor of the pel fusion time. Meanwhile, on the clinical series the transition of gastric secretion as the ulcer stage was observed. On experiments, the author knew that the gastric mucous membrane was more resistent to the acid than the duodenum and the reduction of mucus secretion by the intravenous administration of prednisolone induced more rapid formation of gastric ulcer.
On clinical observation the gastric mucous secretion was markedly less in the active stage of gastric ulcer than the scarring one. On the contrary the acid was thought to be more potent factor in the pathogenesis of duodenal ulcer. From these facts the author concluded that the major factor in the pathogenesis of gastric ulcer was different from that of duodenal ulcer.