An Experimental Study on Gastric Hypersecretion after Ligation of Pancreatic Duct

The Changes of Serum Gastrin Levels

Abstract

The present study was performed to investigate gastric secretion and serum gastrin levelsafter ligation of the pancreatic duct in Heidenhain pouch dogs.
The results obtained were summarized as follows:
Serum gastrin levels began to elevate from the second week and reached high levels at the fourth week after a complete pancreatic duct ligation. However, the elevation of serum gastrin levels was not markedly after a simple pancreatic duct ligation. Gastric hypersecretion and hypergastrinemia were confirmed by the oral administration of glycine solution in dogs after a complete pancreatic duct ligation. Ulcer was observed in the stomach or Heidenhain pouch by pathological examination. Glycine-induced gastric hypersecretion and hypergastrinemia could be inhibited by intravenous injection of glucagon.
These results suggested that the origin of oversecreted gastrin after a complete pancreatic duct ligation was mainly from the gastric antrum.