Hepatitis B core 抗体 (anti-HBC) の臨床的意義に関する研究

清沢 研道; 古田 精市; 長田 敦夫; 赤羽 賢浩; 小池 ゆり子; 佐原 勍; 古川 賢一; 飯島 義浩; 山村 伸吉; 小松 敬直; 大森 晶彦; 小田 正幸

doi:10.11405/nisshoshi1964.73.935

Studies on the clinical significance of the antibody to hepatitis B core antigen

Kendo KIYOSAWA, Seiichi FURUTA, Atsuo NAGATA, Yoshihiro AKAHANE, Yuriko KOIKE, Takeshi SAHARA, Kenichi FURUKAWA, Yoshihiro IIJIMA, Shinkichi YAMAMURA, Hironao KOMATSU, Akihiko OMORI, Masayuki ODA

Author information

Kendo KIYOSAWA
Department of Internal Medicine, Faculty of Medicine, Shinshu University
Seiichi FURUTA
Department of Internal Medicine, Faculty of Medicine, Shinshu University
Atsuo NAGATA
Department of Internal Medicine, Faculty of Medicine, Shinshu University
Yoshihiro AKAHANE
Department of Internal Medicine, Faculty of Medicine, Shinshu University
Yuriko KOIKE
Department of Internal Medicine, Faculty of Medicine, Shinshu University
Takeshi SAHARA
Department of Internal Medicine, Faculty of Medicine, Shinshu University
Kenichi FURUKAWA
Department of Internal Medicine, Faculty of Medicine, Shinshu University
Yoshihiro IIJIMA
Department of Internal Medicine, Faculty of Medicine, Shinshu University
Shinkichi YAMAMURA
Department of Internal Medicine, Faculty of Medicine, Shinshu University
Hironao KOMATSU
Department of Internal Medicine, Faculty of Medicine, Shinshu University
Akihiko OMORI
Department of Internal Medicine, Faculty of Medicine, Shinshu University
Masayuki ODA
Department of Internal Medicine, Faculty of Medicine, Shinshu University

Keywords: Hepatitis B surface antigen (HBs-Ag), antibody to HBs-Ag (anti-HBs), Hepatitis B core antigen(HBc-Ag), antibody to HBc-Ag (anti-HBc)

JOURNAL FREE ACCESS

1976 Volume 73 Issue 8 Pages 935-940

DOI https://doi.org/10.11405/nisshoshi1964.73.935

Details

Abstract

The antibody to hepatitis B core antigen (anti-HBc) titer in sera of 28 asymptomatichepatitis B surface antigen carriers (AsC) and 143 patients with various liver diseases wassurveyed by indirect immunofluorescent technique. The relationship between the anti-HBc titer and the appearance of HBc-Ag in the liver was studied.
The anti-HBc titer was low in AsC, compairing to that in chronic liver diseases. Especiallythe highest anti-HBc titer was observed in chronic active hepatitis. The positive casesof HBc- Ag in liver tissue revealed higher anti-HBc titer than the negative cases. No HBc-Ag was found in liver tissue of the cases with anti-HBc titer less than 2³.
These results suggested that the anti-HBc titer in the serum might be closedly relatedto the injury state of the liver and the active replication of hepatitis B virus in liver.

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