ELECTRON MICROSCOPIC STUDIES ON THE REGENERATING GASTRIC MUCOSA AND THE LAMINA PROPRIA MUCOSAE IN RATS

Abstract

Results of electron microscopic studies on connective tissue cells in the regenerating mucosa using experimental gastric ulcers are presented.
At the early ulcer stage, phagocytic cells, especially macrophages mainly developed in the connective tissue which was marginal zone of the ulcer.
Thereafter, fibroblasts developed and produced collagen fibers and matrix. Proliferation and differentiation of the regenerating mucosal cells occured in this connective tissue. Sometimes, lymphocytes and mesenchymal cells were observed between the regenerating mucous epithelial cells.
At the late stage, the eosinophiles, plasma cells and macrophages occasionally were observed near the capillaries in the lamina propria of the regenerating mucosa. These cells were kept in contact each other.
It seems that the connective tissue cells of the stomach achieve the important role of lead cell with the proliferation and differentiation of the regeneratting mucosa.