COMPARATIVE STUDIES OF EXPER.IMENTAL PANCREATIC INJURIES WITH HUMAN CHRONIC PANCREATITIS BY ELECTRON MICROSCOPY

Abstract

Experimental pancreatic injuries were made to investigate the pathogenesis of chronic pancreatitis as follows: 1. incomplete ductal ligation, 2. intraabdominal ethionine administration, 3. low protein feeding, 4. intra-pancreatic Freund's adjuvant injection, 5. chronic ethanol administration. Histological findings of these materials by electron microscopy on acinar and centroacinar regions were compared with those of human chronic pancreatitis. Both of the lesions in acinar cells and centroacinar architectures including acinar lumens appeared to be intricately correlated with the pathogenesis and the development of chronic pancreatitis. In chronic alcoholic pancreatic injuries, the pathological alterations of the latter were dominant.