Abstract
In order to determine gastrin release into blood following an appropriate stimulation and clarify pathophysiological features in gastroduodenal diseases, bouillon test (B test) wasexamined.
Fasting serum gastrin levels of normal control subjects were 102±14.1 pg/ml and the levels increased up to 178±60.0 pg/ml (p<0.05) at five minutesafter the B test.The B test was carried out on various gastroduodenal diseases and the response in increaseof serum gastrin level was classified into three types of “high”, “normal” and “low” reactions. Of 30 patients with gastroduodenal diseases, 16.7%, 20.0% and 63.3%of cases belonged to high, normal and low reaction types, respectively. These findings suggested that moreor less different mechanisms in the gastrinrelease from the normal control subjects should be involved in relation to the disease states.
There were, however, highly significant correlations between fasting serum gastrinlevels or the peak gastrin levels in the B test and gastrin-like immunoreactivities of thehuman antral mucosae, showing r=0.65 (p<0.01) and r=0.72 (p<0.001), respectively.
Summarizing the results, serum gastrin response in the B test seems to be parallel to the functional G cell mass in the antral mucosae, and clinical availability of the B test was discussed.
