Effect of gastrin on proliferation of rat fundic mucosa in tissure culture

Comparative study with synthetized human gastrin and tetragastrin

Abstract

The effect of sythetized human gastrin I or tetragastrin on epithelioid cell colony of the rat fundic mucosa in tissure culture was observed. The synthetized human gastrin in a concentration of 10γ/ml in culture medium did not effect on maintenance of epithelioid cell colony. The colony was disappered within about 4 weeks under gastrin treatment as long as that of control group. ³H-thymidine incorporation was increased significantly under the treatment of synthetized human gastrin (0.05γ/ml) or tetragastrin (10γ/ml), respectively.
Both the gastrins showed the proliferative effect on the cultured fundic mucosal cells, and this effect of synthetized human gastrin was about 20 fold powerful than that of tetragastrin.