1978 Volume 75 Issue 7 Pages 980-989
The present study was done to investigate the influence of pancreatic duct ligation on gastric secretion in dogs with Heidenhain pouches. The following tests in response to a test meal (Dog food 300g) with or without oral administration of pancreatic enzymes (Berizym: 3g/kg) were studied at the control period and every one week for a period of one to six weeks after pancreatic duct ligation (PDL); gastric acid secretion, serum gastrin levels, plasma pancreatic glucagon levels (IRG) and insulin levels (IRI). The results obtained are summarized as follows: Acid outputs in response to a test meal with administration of pancreatic enzymes were significantly inhibited, compared with those without administration of pancreatic enzymes. Serum gastrin levels began to increase from the second week and continued to increase until the sixth week after PDL, showing no effect of pancreatic enzymes on the serum gastrin levels. Also, plasma pancreatic glucagon levels began to increase from the first week after PDL, with a significant increase in case of administration of pancreatic enzymes, compared with those without administration of pancreatic enzymes. Plasma insulin levels were higher than those before PDL at the first week after PDL, but decreased after the second week following ligation of the pancreatic ducts.
From these results, it is presumed that gastric hypersecretion after PDL would have complicated relations with pancreatic glucagon, GIP as well as antral gastrin.