STUDIES ON THE DEVELOPMENT OF INTESTINAL METAPALSIA, WITH SPECIAL REFERENCE TO HISTOCHEMICAL AND CYTOCHEMICAL OBSERVATIONS OF MUCOSUBSTANCES

Abstract

Department of Surgery and Pathology Division of Central Laboratory, Shinshu University School of Medicine, Matsumoto 390
Processes in the development of intestinal metaplasia of the stomach were investigated from the morphological and histochemical approaches using light and electron microscopic techniques. The specimens taken from 38 gastric carcinomas and 15 gastric and/or duodenal ulcers were subjected to this study. Morphological appearances of the intestinal metaplasia observed in routine examination with hematoxylin and eosin staining was able to be divided into complete and incomplete metaplasia by the light and electron microscopic histochemical stainings of the mucosubstances. The columnar cells at the area of the incomplete metaplasia had both the properities of the intestinal and the gastric foveolar epithelia. The incomplete metaplasia as well as the complete metaplasia arose from the generative cells at the isthmus of the gland. The generative cells, however, sometimes gradually transformed to produce the complete metaplastic cells. The two processes of the development of the intestinal metaplasia were proposed and discussed.