CLINICOHISTOPATHOLOGICAL STUDY ON "BORDERLINE ATYPICAL EPITHELIAL LESION" OF THE HUMAN STOMACH WITH SPECIAL REFERENCE TO HISTOGENESIS

Abstract

Histological examinations were made on the 27 "borderline atypical epithelial lesions" found at the 22 surgical specimens of the human stomach. Following conclusions were drawn regarding their histogenesis.
(1) Although atypical epithelia showed some tendency of differentiation toward metaplastic intestinal epithelia, they were considered to be a manifestation of abnormal differentiation at relatively early stage of intestinal metaplasia from porper gastric glands rather than the development from fully matured metaplastic intestinal epithelia.
(2) Atypical epithelia were considered to be arisen mainly from the superficial layer of the mucosa.
(3) Serial sections of one atypical epithelial lesion revealed proliferations of atypical glands with frequent budding and anastomosis of adjacent glandular lumen, which might suggest neoplastic nature of this atypical epithelial lesion.