EFFECTS OF ENDOGENOUS AND EXOGENOUS SECRETIN ON PLASMA GLUCAGON AFTER TOTAL PANCREATECTOMY

Abstract

The effect of exogenous and endogenous secretin on plasma glucagon reacting to 30K antibody was investigated in totally pancreatectomized dogs.
One clinical unit per kilogram of intravenously administered secretin (Eisai) caused no significant change in the plasma glucagon levels of normal dogs, but in the totally pancreatectomized dogs, slight suppression of glucagon secretion was observed.
The administration of 7 clinical units of secretin caused a significant suppression of plasma glucagon in normal as well as the totally pancreatectomized dogs.
Intraduodenally infused 0.1 N HCL gave rise to a rapid increase in the plasma secretin level, which showed no significant effect on the plasma glucagon of normal dogs.
After total pancreatectomy, basal secretin levels increased gradually, and endogenous secretin released by duodenal acidification brought about a significant suppression of plasma glucagon levels.
Thus, in the totally pancreatectomized dogs, both plasma secretin levels and the sup-pressive effect of endogenous and exogenous secretin on plasma glucagon were significantly enhanced.