1980 Volume 77 Issue 12 Pages 1900-1904
In the preceding paper, the authors reported that the pattern of the intestinal flora usually changes during continuous intake of immunosuppressive or anticancer drugs. In this study, the possible effect of the continuous intake of lactobacilli on the pattern of the microflora was examined during the administration of these drugs in mice of a uniform genetic strain (C3H/He).
Intestinal bacteria were isolated from the feces and identified by the method described in the previous report.
It was noted that the concomitant intake of these drugs with lactobacilli caused increased numbers of lactobacilli and decreased numbers of Escherichia coli. Other strains of lactobacillus than those given were also increased in the digestive canal in the mice. Lactobacilli were found in large numbers in the stomach, and small and large intestines.
After the administration of lactobacilli was discontinued, they remained in the digestive canal if administration had continued for 20 weeks.
These findings suggest that proliferation of lactobacilli instead of Escherichia coli may be beneficial in preventing the side effects of immunosuppressive or anticancer drugs.