EFFECTS OF WEIGHT REDUCTION ON ABNORMAL SERUM TRANSAMINASE VALUES, HYPERLIPIDEMIA AND ORAL GLUCOSE INTOLERANCE IN MALE OBESE SUBJECTS

Abstract

Serum GOT and GPT values, serum lipid levels and oral glucose tolerance were evaluated in 50 male obese subjects before and after weight reduction by caloric restriction.
1) The high incidence of abnormal S-GOT or S-GPT values before weight reduction markedly decreased after weight reduction of 5% as % ideal bw (pre-weight reduction GOT 52.9%, GPT 64.7%; post-weight reduction GOT or GPT: 11.8%). After weight reduction over 5% as % ideal bw all subjects had normal values of both transaminase activities.
2) The frequency of hypertriglyceridemia decreased after weight reduction over 5% as % ideal bw (pre-weight reduction 54.6%; post-weight reduction 9.0%), and that of hypercholesterolemia decreased from 64.7 to 5.9% after weight reduction over 10% as ideal bw.
3) The improvement of abnormal glucose tolerance before weight reduction was found in about 40% after weight reduction up to 20% as % ideal bw.