1981 Volume 78 Issue 3 Pages 701-707
In order to obtain information concerning the mechanism of hepatic uptake and biliary excretion of 99mTc-labeled hepatobiliary imaging agents, the effect of simultaneous administration of sulfobromophthalein (BSP) in rats was studied for 6 different 99mTc-labeled preparations with regard to their plasma clearances and tissue distributions of intravenously administered radioactive preparations.
The biliary excretion as assessed by the small intestinal distribution of radioactivity 30 min after iv injection of materials was higher for BIDA and PIPIDA (70-75 percent of the administered dose) compared with that of HIDA and PI (50-60%), and conversely the urinary excretion was lower for the former drugs than the latter two. The inhibitory effects of BSP loading on the hepatic uptake and subsequent biliary excretion of materials were observed for all 6 materials tested, but the BSP effect was more prominent for BIDA & EHIDA in plasma clearance and for BIDA & PIPIDA in tissue distribution of 99mTc-activity.
These new 99mTc-labeled compounds not only were useful clinically but also suggested their possible contribution to the further understandings of physiology of hepatobiliary system.