THE SIGNIFICANCE OF SERUM IMMUNOREACTIVE CHOLYL- GLYCINE AND SULFOLITHOCHOLYLGLYCINE IN DETECTION

AND DIFEERENTIAL DIAGNOSIS OF CHOLELIASIS

Abstract

Serum immunoreactive cholylglycine (CG) and sulfolithocholylglycine (SLOG) were measured and their ratio (C/S) was calculated to differentiate cholelithiasis from other hepatobiliary disorders. Low CG, high SLCG and low C/S ratio were observed in cholelithiasis without rentogenologically proven calcification. These values were CG 33.2±28.2tg/dl, SLCG 114.7±66.6μg/dl and the C/S ratio 0.32±0.32. These changes were not detected in cholelithiasis with rentogenologically proven calcification.
Loading of UDCA for two weeks produced a marked increase of SLCG in cholelithiasis without rentogenologically proven calcification, while in cholelithiasis with rentogenologically proven calcification there were no changes in the conjugated bile acids.
These results indicated that the measurement of CG and SLOG is important in the detection of gallstones and their differentiation from other hepatobiliary disorders. Moreover it is felt that these tests could be very important in separation of UDCA sensitive cases from UDCA resistent cases.