1981 Volume 78 Issue 7 Pages 1459-1465
The effect of pancreatic juice diversion from the duodenum on plasma secretin level and pancreatic secretion after meal ingestion were investigated in 5 dogs with pancreatic fistula and gastric canula.
Exclusion of pancreatic juice resulted in a mean peak secretin level of 80.6±18.2 pg/ml and 8.3±1.7 ng/ml/150 min. of integrated scretin response for 150 minutes after meal ingestion; this coincided with a significant increase in pancreatic volume and bicarbonate out put. However, reinfusion of the collected pancreatic juice decreased the response of secretin secretion; a mean peak level of 57.0±15.0 pg/ml and the integrated secretin secretion of 5.0±0.8 ng/ml/150 min, which was acompanied by a decrease in pancreatic volume and bicarbonate output.