1981 Volume 78 Issue 9 Pages 1707-1712
Gastric acid secretion, serum gastrin and antral mucosal gastrin concentration of endoscopically biopsied specimens were measured in 7 patients with inflammatory bowel disease before total parenteral nutrition (TPN) and after averaging 29.4 days on TPN.
Basal acid output increased significantly (p〈0.05). Maximal acid output and mucosal gastrin concentration were similar before and during TPN. Integrated gastrin response to test meal tended to decrease (p〈0.1). Therefore it was suggested that fundic atrophy did not occur during TPN performed for as long as long as one month.