HETEROTRANSPLANTATION OF HUMAN GASTRIC CARCINOMAS INTO NUDE MICE

III. Histological and Histochemical Studies on Transplantable Human Signetring Cell Carcinoma in Nude Mice

Abstract

Histological and histochemical studies were made on human signet-ring cell carcinomas transplanted serially into BALB/cAJcl-nu male nude mice. The transplantability was 100% and the serial transplantation is now the 19th passage. The tumor growth became rapid by serial transplantation and the doubling time was 16.8±7.7 days at the fist passage and it became shorter as 8.1±1.4 days. The histology of signet-ring cell carcinoma was retained in nude mice. The signet-ring cell carcinoma secretes mainly non-sulfated acid mucin and little sulfated acid mucin. The secreting function of the acid mucin by the signet-ring cell carcinoma has been maintained in nude mice.