1982 Volume 79 Issue 8 Pages 1612-1618
The influence of obstructive jaundice on the pancreatico-trophic effect of trypsin inhibitor was studied in rats following laparotomy.
The wet weight of the pancreas in rats treated with trypsin inhibitor was 1.6 times that of untreated rats, whereas in rats with obstructive jaundice, the weight in trypsin inhibitor treated animals was 2.2 times that of untreated animals. The protein content of the pancreas in treated rats was 2.4 times that of untreated, but was unaffected by obstructive jaundice. Obstructed rats treated with trypsin inhibitor showed a decrease in total amylase content of the pancreas and histologically a decrease in the zymogen granules of the pancreatic acinar cells compared with unobstructed treated animals.
Obstructive jaundice significantly increased the pancreatico-trophic effect of trypsin inhibitor, and this may be due to a prolongation of effect of the pancreatico-trophic hormone(s) induced by trypsin inhibitor in obstructed animals.