Nippon Shokakibyo Gakkai Zasshi
Online ISSN : 1349-7693
Print ISSN : 0446-6586
THE INFLUENCE OF OBSTRUCTIVE JAUNDICE ON THE PANCREATIC TROPHIC EFFECT OF TRYPSIN INHIBITOR IN RATS
Nobuo BABATakashi SUZUKITakayoshi TOBE
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Keywords: Trypsi nInhibitor
JOURNAL FREE ACCESS

1982 Volume 79 Issue 8 Pages 1612-1618

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Abstract

The influence of obstructive jaundice on the pancreatico-trophic effect of trypsin inhibitor was studied in rats following laparotomy.
The wet weight of the pancreas in rats treated with trypsin inhibitor was 1.6 times that of untreated rats, whereas in rats with obstructive jaundice, the weight in trypsin inhibitor treated animals was 2.2 times that of untreated animals. The protein content of the pancreas in treated rats was 2.4 times that of untreated, but was unaffected by obstructive jaundice. Obstructed rats treated with trypsin inhibitor showed a decrease in total amylase content of the pancreas and histologically a decrease in the zymogen granules of the pancreatic acinar cells compared with unobstructed treated animals.
Obstructive jaundice significantly increased the pancreatico-trophic effect of trypsin inhibitor, and this may be due to a prolongation of effect of the pancreatico-trophic hormone(s) induced by trypsin inhibitor in obstructed animals.

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© The Japanese Society of Gastroenterology
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