BLOOD COAGULATION AND FIBRINOLYSIS IN PATIENTS WITH ULCERATIVE COLITIS

Abstract

Activities of blood coagulation and fibrinolytic systems were investigated. Platelet count was increased in ulcerative colitis, especially in the active stage. Of the coagulation factors, factor VIII was significantly increased in ulcerative colitis as compared with the normal healthy control. Antithrombin III was increased, on the other hand, α₁ antitrypsin and alpha;₂ macroglobulin significantly diminished. Thromboelastogram showed an increase of Ma value. In fibrinolytic system, euglobulin lysis time was shortened, and plasminogen activity was increased. The present data indicated that the blood coagulation system was activated in ulcerative colitis, particularly in the active stage.