Nippon Shokakibyo Gakkai Zasshi
Online ISSN : 1349-7693
Print ISSN : 0446-6586
STUDIES ON THE DRUG-INDUCED INJURY AND CHANGES OF MEMBRANE STRUCTURE IN THE ISOLATED LIVER CELLS
Takayasu MATSUIHisanori KITAGAWAYuichi KOBAYASHIYasuhiro MIZOGUCHITakeyuki MONNASukeo YAMAMOTOSeiji MORISAWA
Author information
Keywords: GOT
JOURNAL FREE ACCESS

1983 Volume 80 Issue 1 Pages 55-60

Details
Abstract

The effects of various drugs on the isolated liver cells were investigated in vitro. When chlorpromazine (CPZ), ajmaline (AJ), cephaloridine (CER), cephalothin (CET) or carbon tetrachloride (CCl4) were added to the isolated liver cell suspension and cell viability was measured by a trypan blue dye exclusion test, the order of cytotoxic effects of these drugs were: CCl4> CPZ>AJ>CER=CET. The order of the capability to induce the lipid peroxide formation in hepatocytes were: CCl4>CER>AJ=CET>CPZ.
However, the order of the release of GOT enzyme activity from the hepatocytes were: CCl4>CPZ=AJ>CER=CET. Moreover, surface scanning of the isolated hepatocytes revealed that these drugs produce more or less morphological changes in membrane strcuture.

Content from these authors
© The Japanese Society of Gastroenterology
Previous article Next article
feedback
Top