1983 Volume 80 Issue 1 Pages 55-60
The effects of various drugs on the isolated liver cells were investigated in vitro. When chlorpromazine (CPZ), ajmaline (AJ), cephaloridine (CER), cephalothin (CET) or carbon tetrachloride (CCl4) were added to the isolated liver cell suspension and cell viability was measured by a trypan blue dye exclusion test, the order of cytotoxic effects of these drugs were: CCl4> CPZ>AJ>CER=CET. The order of the capability to induce the lipid peroxide formation in hepatocytes were: CCl4>CER>AJ=CET>CPZ.
However, the order of the release of GOT enzyme activity from the hepatocytes were: CCl4>CPZ=AJ>CER=CET. Moreover, surface scanning of the isolated hepatocytes revealed that these drugs produce more or less morphological changes in membrane strcuture.