STUDIES ON RIBONUCLEASE IN THE PANCREATIC JUICE OF PATIENT WITH PANCREATIC DISEASE

II. Secretory Pattern of Ribonuclease, Amylase and Immunoreactive Trypsin in Duodenal Juice During Pancreozymin Secretin Test

Abstract

In patient with pancreatic disease, activity of ribounclease (RNase), amylase level and immunoreactive trypsin (IRT) in duodenal juice obtained during pancreozymin secretin test were measured and their secretory patterns were studied.
Secretory pattern of RNase in the group with pancreatic carcinoma was generally lower titre than those with non pancreatic disease or suspected chronic pancreatitis, but not specific for pancreatic carcinoma. So far as correlation among three enzymes after administration of secertin was concerned, 80% of the group with pancreatic carcinoma were in the ranges of 50 to 180units/ml of RNase activity and 40, 000 to 70, 000 Somogyi units/dl of amylase activity. Therefore determination of these enzymes in duodenal juice is useful for the diagnosis of pancreatic carcinoma.
In the group without pancreatic disease, the secretory pattern of RNase and amylase was parallel. In the disease groups, however the three enzymes showed different secretory pattern. As a result, it is suggested that secretory pattern of pancreatic enzymes is non parallel in patient with pancreatic desease.