EFFECT OF SELECTIVE PROXIMAL VAGOTOMY ON GASTRIC G-, D- AND EC-CELL DENSITY IN DOG

Abstract

The numbers of G-cells, D-ccells and EC-cells per unit area were investigated by the specific immunoperoxidase staining technique in canine antral and corporal mucosa after selective proximal vagotomy (SPV). The G-cell density became significantly higher three months after SPV than that of pre-SPV, and the higher density of G-cell persisted during two years after SPY. On the other hand, the D-cell density increased later, reaching a peak at one year after SPV in the antrum and two years after in the corpus. The EC-cell density in the antrum became significantly higher one year after SPY and decreased significantly lower two years after SPY than that of control. On the other hand, the EC-cell density in the corpus increased significantly higher one year after SPY, and the higher density of EC-cell persisted during two years after SPY.
In conclusion, it is suggested that the endocrine status of gastric G-, D- and EC-cells is altered by SPV.