RELATIONSHIP BETWEEN SERUM HBV-DNA POLYMERASE ACTIVITY AND HBe SYSTEM

Two Types of the Changes of DNA Polymerase activity and Transaminase

Abstract

The correlation between serum HBV-DNA polymerase (DNA-P) activity and HBe antigen/anti-HBe system was examined in 216 samples, and relationship between DNA-P activity and transaminase (GPT) value was also investigated in 17 untreated patients with HBs antigen positive liver diseases.
DNA-P activity correlated significantly with the concentration of HBe antigen detected by micro-Ouchterlony method. On the contrary, this activity showed almost negative in the anti-HBe positive samples, and the correlation between DNA-P activity and the titer of HBe antigen by radioimmunoassay or the titer of HBs antigen was respectively low. In addition, two cases of chronic active hepatitis which were anti-HBe positive were persistently high in DNA-P activity. These facts suggest that some essential difference might be exist in these two HBV markers.
Twelve cases of chronic active hepatitis were separated into two groups in relation to DNA-P activity and transaminase. One of them showed the rapid elevation of DNA-P activity followed by acute exacerbation of transaminase, and the other revealed no relation between them.