THE SECRETORY COMPONENT AND IMMUNOGLOBULINS IN HUMAN DUODENAL JUICE OF THE PATIENTS WITH PANCREATIC DISEASES

Abstract

Secretory component (SC) and immunoglobulins (Igs) in human duodenal juice obtained by PS test were measured and their significance in the pancreatic disease were studied. SC and Igs were determined by RIA method and single radial immunodiffusion method, respectively.
Concentration of SC and IgA were elevated in pancreatic cancer and chronic pancreatitis when compared with the other pancreatic disease groups. Furthermore, IgA in S2 and S3 fractions (10 to 20 minutes and 20 to 40 minutes periods after secretin provocation) was significantly increased in pancreatic cancer comparing to chronic pancreatitis (p<0.02 and p<0.05, respectively).
There were many fractions of PS test in which concentration and quantity of IgM were significantly increased in acute pancreatitis when compared with the other pancreatic diseases.
Since, no correlation between pancreatic exocrine secretion and secretion of SC in the pancreatic juice could be found, they were regulated by different mechanisms. Furthermore, possibility of Igs secretion by simple inflammatory exsudation was excluded.