MEASUREMENT OF ELECTRIC LIVER RESISTIVITY IN CHRONIC LIVER DISEASE

Abstract

The liver resistivity was determined in 23 rats with chronic liver damage induced by CCl₄ and 61 patients with chronic liver disease.
In rats, the values were 1.95±0.23 (×10³ohm cm) in Fibrosis group, 1.74±0.17 in LC(I) group, 1.39 ±0.15 in LC(II) group and 2.24±0.22 in Control group, with significant difference (p<0.01) between the Control and every CCl₄-treated group.
In patients, they were 1.88±0.24 in CIH group, 1.66±0.23 in CAH group, 1.27±0.19 in LC group and 2.24±0.30 in Control group, with significant difference (p<0.01) or significant tendency of difference (p<0.05) between the Control and each group. A significant correlation was found between the liver resistivity and the blood flow index of the liver, Ch-E, γ-gl and ICG(R15) in liver function tests or prothrombin time in patients.
The decrease in liver resistivity detected in rats with chronic liver damage or patients with chronic liver disease seemed to be connected with degeneration of liver tissue or advanced liver fibrosis.