EFFECTS OF DIETARY FACTORS AND FECAL BILE ACIDS ON DMH INDUCED COLON CANCER IN RAT

Abstract

In an attempt to evaluate the effects of dietary factors and fecal bile acids on colon carcinogenesis, Donryu rats were maintained on one of the diets containing high fat, 1.5% of colestipol, high fiber, high fat plus high fiber or control and were given subcutaneous injection of DMH, and fecal bile acids were measured with high performance liquid chromatography.
The number of colon tumors was increased in rats fed high fat diet and colestipol diet compared with control diet, and in these groups fecal bile acids were increased, too.
However, in high fiber diet group the number of colon tumors was decreased, though fecal bile acids were not decreased.
The number of colon tumors in high fat plus high fiber diet was decreased significantly compared with that in high fat diet.
These results indicate that high fiber diet is more important than high fat diet on colon carcinogenesis in rat.