茵〓蒿湯の胆汁分泌促進作用と催胆汁うつ滞因子の影響

阪上 吉秀; 溝口 靖紘; 宮島 慶治; 筒井 ひろ子; 関 守一; 山本 祐夫; 竹田 茂文; 油田 正樹; 森沢 成司

doi:10.11405/nisshoshi1964.82.2608

EFFECTS OF THE CHINESE PRESCRIPTION "INCHINKO-TO" ON INTRAHEPATIC CHOLESTASIS INDUCE BY THE CHOLESTATIC FACTOR

Yoshihide SAKAGAMI, Yasuhiro MIZOGUCHI, Keiji MIYAJIMA, [in Japanese], [in Japanese], Sukeo YAMAMOTO, Shigefumi TAKEDA, Masaki ABURADA, Seiji MORISAWA

Author information

Yoshihide SAKAGAMI
The Third Department of Internal Medicine, Osaka City University Medical School
Yasuhiro MIZOGUCHI
The Third Department of Internal Medicine, Osaka City University Medical School
Keiji MIYAJIMA
The Third Department of Internal Medicine, Osaka City University Medical School
[in Japanese]
The Third Department of Internal Medicine, Osaka City University Medical School
[in Japanese]
The Third Department of Internal Medicine, Osaka City University Medical School
Sukeo YAMAMOTO
The Third Department of Internal Medicine, Osaka City University Medical School
Shigefumi TAKEDA
Tsumura Research Institute for Pharmacology
Masaki ABURADA
Tsumura Research Institute for Pharmacology
Seiji MORISAWA
The First Department of Biochemistry, Osaka City University Medical School

Keywords: erythritol clearance

JOURNAL FREE ACCESS

1985 Volume 82 Issue 10 Pages 2608-2612

DOI https://doi.org/10.11405/nisshoshi1964.82.2608

Details

Abstract

The effects of "Inchinko-to", a Chinese prescription frequently applied to hepatobiliary diseases, on bile flow were investigated using the erythritol clearance methods. As a result, it was found that when Inchinko-to was administered into the duodenum of normal rats, bile flow was enhanced. Moreover, it seemed to affect the bile formation mainly in the bile canaliculi but not the distal fluid transfer. Furthermore, Inchinko-to significantly blocked the reduction of bile flow induced by the cholestatic factor.

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