抗生剤の胆汁中移行に対するウルソデオキシコール酸の影響

早川 富博; 東 克謙; 片桐 健二; 宮治 真; 角鹿 精二; 稲熊 秀樹; 遠山 一太; 星野 信; 伊藤 誠; 武内 俊彦; 山本 俊幸

doi:10.11405/nisshoshi1964.82.483

EFFECT OF URSODEOXYCHOLIC ACID ON BILIARY EXCRETION OF CEFOTIAM IN PERCUTANEOUS TRANSHEPATIC CILIARY DRAINAGE PATIENT

Tomihiro HAYAKAWA, Katsuyoshi HIGASHI, Kenji KATAGIRI, Makoto MIYAJI, Seiji TSUNOKA, Hideki INAGUMA, Kazufuto TOHYAMA, Modoto HOSHINO, Makoto ITO, Toshihiko TAKEUCHI, Toshiyuki YAMAMOTO

Author information

Tomihiro HAYAKAWA
1st Department of Internal Medicine, Medical School, Nagoya City University
Katsuyoshi HIGASHI
1st Department of Internal Medicine, Medical School, Nagoya City University
Kenji KATAGIRI
1st Department of Internal Medicine, Medical School, Nagoya City University
Makoto MIYAJI
1st Department of Internal Medicine, Medical School, Nagoya City University
Seiji TSUNOKA
1st Department of Internal Medicine, Medical School, Nagoya City University
Hideki INAGUMA
1st Department of Internal Medicine, Medical School, Nagoya City University
Kazufuto TOHYAMA
1st Department of Internal Medicine, Medical School, Nagoya City University
Modoto HOSHINO
1st Department of Internal Medicine, Medical School, Nagoya City University
Makoto ITO
1st Department of Internal Medicine, Medical School, Nagoya City University
Toshihiko TAKEUCHI
1st Department of Internal Medicine, Medical School, Nagoya City University
Toshiyuki YAMAMOTO
Nagoyashi-Kohseiin Geriatric Hospital

JOURNAL FREE ACCESS

1985 Volume 82 Issue 3 Pages 483-488

DOI https://doi.org/10.11405/nisshoshi1964.82.483

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Abstract

Effects of ursodeoxycholic acid (UDC) administration and bile refeeding on biliary excretion of cefotiam (CTM) were studied in eight patients with percutaneous transhepatic biliary drainage (PTBD) for obstructive jaundice.
Peak concentration of CTM in the bile and biliary output of CTM were significantly increased by UDC administration, and slightly increased by bile refeeding. There was a significant correlationship between CTM and bile acid in biliary output (p<0.01).
It is suggested that UDC administration is useful in preventing biliary infection in PTBD patients, and that UDC is one of the important factors affecting biliary excretion of CTM.

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