Nippon Shokakibyo Gakkai Zasshi
Online ISSN : 1349-7693
Print ISSN : 0446-6586
VALUE OF BT-PABA TEST WITH SERUM PABA AS A PANCREATIC FUNCTION TEST
Yoshinobu TAKEDATakashi AMATSU[in Japanese]Hideki TADAJunichi TUKIYAMATsukasa ITABASHIWeiming LIMototaka OHURATohru FUJITAKazuo MAJIMASaburo OHSHIBA
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Keywords: PFD
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1985 Volume 82 Issue 7 Pages 1742-1747

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Abstract

0.5g of N-benzoyl-L-tyrosyl-PABA (BT-PABA) was orally administered to 20 patients with chronic pancreatitis and to 10 control subjects. 1 and 2 hours after the administration, serum levels of PABA were determined, and the higher value of the two, the maximal value of serum PABA (MS-PABA), was chosen as the index of the exocrine pancreatic function. In order to estimate the clinical efficiency of the above stated MS-PABA test, its results were compared with those of pancreozymin secretin test (PS test) and of conventional urinary PABA test which takes 6 hours (6HU-PABA test). MS-PABA in patients with decrease in one out of three PS test parameters (Moderate Group) and those with decrease in two or three (Severe Group) revealed statistically significant reduction compared with cortrols. As to the comparison of MS-PABA and 6HU-PABA, the positive ratio of the former was 6/7 and that of the latter was 7/7 for Severe Group, and for Moderate Group both tests produced the same positive ratio of 3/5, whereas in patients with chronic pancreatitis who showed normal PS test results, positive ratios of MS-PABA and 6HU-PABA were 2/8 and 4/8 respectively. Thus, it is concluded that MS-PABA test is particularly valid in diagnosis of moderate and severe chronic pancreatitis.

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© The Japanese Society of Gastroenterology
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