EXPERIMENTAL STUDY ON EFFICACY OF CIMETIDINE, 16, 16-dm PGE₂ AND VAGOTOMY EXERTED TO HEPATIC REGENERATION IN PREVENTION OF STRESS ULCER AFTER HEPATECTOMY

Abstract

The following conlusions were acquired after experimental study of the efficacy of cimetidine, 16, 16-dmPGE₂, and vagotomy for hepatic regeneration in the prevention of stress ulcers after hepatectomy. (1) The onset of water stress ulcers was noticeably lessened in all three groups. (2) The number of cases of endocytosis after hepatectomy of ³H-thymidine decreased dramatically in the vagotomy group. The rate also decreased in the cimetidine and the 16, 16-dmPGE₂ groups. The decreases were evident for thymidine kinase activity and the amount of DNA for all three groups. (3) The peak value in the mitotic indedx of the vagotomy group decreased, and the rate of hepatic regeneration was noticeably lower. We concluded from these three facts that the vagotomy operation is an inadequate treatment method for preventing stress ulcers after hepatectomy.