STUDIES ON SERUM LEVELS OF APOPROTEIN IN PATIENTS WITH LIVER DISEASE

Abstract

Serum levels of apoprotein A-I, A-II, C-II and E were measured in 137 patients with liver disease including 28 of acute hepatitis, 41 of chronic hepatitis and 68 of liver cirrhosis. Controls consisted of 14 healthy adults.
Serum levels of apoprotein A-I and A-II in acute phase of acute hepatitis were significantly lower than controls, and gradually returned to normal levels during convalecent phase. In patients with chronic liver disease, apoprotein A-I, A-II and C-II were lowest in liver cirrhosis, and followed by chronic active hepatitis and chronic inactive hepatitis. By contrast, serum levels of apoprotein E were higher in acute hepatitis. The serum levels of apoprotein A-I, A-II and C-II were significantly correlated with levels of serum γ-globulin, TTT, ZST, ChE, normotest and R15 ICG.
It was concluded that measurement of serum apoproteins was useful in estimating liver function of patients with liver disease.