AN ESTIMATION OF FUNCTIONAL RESERVE OF LIVER IN LIVER CIRRHOSIS BY MEANS OF PABA TEST

Abstract

In the measurement of ICG Rmax, an error is apt to be made under the condition of inaccurate dose and/or time. To develop easier examination, we administered 1.02g PABA orally, and measured its density in serum and the rate of excretion in urine for 6 hours to compare liver cirrhosis with normal control. Total, free and conjugated serum PABA concentration was measured, and statistically significance (p<0.05) was recognized between two groups, excepting the points after 120min of free PABA. Statistically significance (p<0.05) was also recognized in cumulative area on the graph for 6 hours. Orally administered PABA is immeadiately absorbed by intestine, conjugated in liver cell, flowed out to blood and excretd from kidney. Correlation was recognized between serum PABA and ICG Rmax, and the movement of serum PABA was speculated to reflect number of functional liver cell.