EFFECTS OF PROSTAGLANDIN IN AN EXPERIMENTALLY-INDUCED ACUTE HEPATIC FAILURE MODEL

Abstract

When heat-killed Propionibacterium acnes is intravenously injected into mice and seven days later, a small amount of gram-negative lipopolysaccharide is also intravenously injected, most of the mice die of massive necrosis. However, when prostaglandin (PG) was administered during this experimental induction of acute hepatic ailure, the viability of the mice increased and the histological changes of the liver remarkably improved.
These results suggested that PG was effective in our experimental acute hepatic failure model. Since there is no definite treatment method for fulminant hepatitis at present, PG may be useful as a clinical treatment in future.