THE STUDY ON THE EFFECT OF OXYGENATION UNDER HIGH PRESSURE (OHP) ON RAT GASTRIC MUCOSA

Abstract

This study on the effect of oxygenation under high pressure (OHP) on gastric mucosa and experimental gastric ulcer in rats showed that (1) in untreated rats, OHP decreased significantly pepsin activity, but there was no significant change in gastric mucosal blood flow, hexosamine contents in gastric mucosa, gastric motility, pH of gastric juice, and gastrin contents in gastric mucosa. (2) The appearance of indomethacin-induced gastric ulcer was significantly inhibited by OHP, but in the water immersion and restraint stress, there was no significant change of ulcer appearance between control and OHP groups. The mechanism by which OHP inhibited the indomethacin-induced ulcer seems that OHP restored significantly gastric mucosal blood flow decreased by indomethacin. However, there was no significant difference of hexosamine contents after indomethacin administration between OHP and control groups. Accordingly, it was thought that OHP was a safe therapeutic maneuver with no side effect and applicable to the treatment of gastric lesion caused by micro-circulatory disturbance.