ラット胃粘膜障害における superoxide dismutase に関する研究 (第2報) インドメタシン潰瘍について

荻野 景規; 岡 紳爾; 松浦 伸二郎; 坂井田 功; 由村 俊二; 松田 和也; 佐々木 敏行; 山本 一成; 岡崎 幸紀; 竹本 忠良

doi:10.11405/nisshoshi1964.84.1389

STUDIES OF SUPEROXIDE DISMUTASE IN RAT GASTRIC MUCOSAL DAMAGE (THE 2ND REPORT)

Pathogenesis of Indomethacin Induced Gastric Ulcer

Keiki OGINO, Shinji OKA, Shinjiro MAZUURA, Isao SAKAIDA, Shunji YOSHIMURA, Kazuya MAZUDA, Toshiyuki SASAKI, Kazunari YAMAMOTO, Yukinori OKAZAKI, Tadayoshi TAKEMOTO

Author information

Keiki OGINO
First Division, Department of Internal Medicine, Yamaguchi University School of Medicine
Shinji OKA
First Division, Department of Internal Medicine, Yamaguchi University School of Medicine
Shinjiro MAZUURA
First Division, Department of Internal Medicine, Yamaguchi University School of Medicine
Isao SAKAIDA
First Division, Department of Internal Medicine, Yamaguchi University School of Medicine
Shunji YOSHIMURA
First Division, Department of Internal Medicine, Yamaguchi University School of Medicine
Kazuya MAZUDA
First Division, Department of Internal Medicine, Yamaguchi University School of Medicine
Toshiyuki SASAKI
First Division, Department of Internal Medicine, Yamaguchi University School of Medicine
Kazunari YAMAMOTO
First Division, Department of Internal Medicine, Yamaguchi University School of Medicine
Yukinori OKAZAKI
First Division, Department of Internal Medicine, Yamaguchi University School of Medicine
Tadayoshi TAKEMOTO
First Division, Department of Internal Medicine, Yamaguchi University School of Medicine

Keywords: superoxide dismutase (SOD), prostaglandin E2

JOURNAL FREE ACCESS

1987 Volume 84 Issue 7 Pages 1389-1393

DOI https://doi.org/10.11405/nisshoshi1964.84.1389

Details

Abstract

It has been suggested that superoxide radicals play an important role in the pathogenesis of gastric mucosal lesion. In this report, it was clarified that superoxide dismutase (SOD) and catalase had inhibitory effect on indomethacin-induced gastric ulcer. SOD had the effect of increasing tendency in gastric mucosal blood flow, inhibitory action on gastric acid secretion and promotive tendency of prostaglandin E₂ synthesis in normal adult rats.
Therefore, it was suggested that inhibitory effect of SOD and catalase on indomethacin-induced gastric ulcer may be due to decrease of inhibition of prostaglandin E₂ synthesis or due to the pathogenesis of indomethacin-induced gastric ulcer in association with endotoxin.

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