1987 Volume 84 Issue 9 Pages 1740-1748
To clarify the role of the sympathoadrenal system in gastric acid secretion, the author evaluated the effects of epinephrine on gastric acid secretion during stimulation with tetragastrin, betazole hydrochloride, bethanechol, and bombesion in dogs with a total gastric fistula. Epinephrine administration reduced gastric acid secretion dose-dependently during stimulation with these agents except betazole hydrochloride. Blood flow in the gastric mucosa did not show direct effects on inhibition of secretion induced by epinephrine. The serum gastrin value markedly increased, but gastric acid secretion decreased following epinephrine administration (2.0μg/kg/min) during stimulation with bombesin. These results suggest that epinephrine secreted from the adrenal medulla directly acts on parietal cells, inhibiting gastric acid secretion.