1987 Volume 84 Issue 9 Pages 1749-1754
PPD and PHA skin tests were carried out on 73 patients with hepatocellular carcinoma (HCC) for the index of cellular immunity at the time of diagnosis established. Studies were mode on the relationship between clinical data and these tests. Clinical data included space occupying rate of HCC, survival time, symptoms and laboratory evaluations. PPD skin test showed an increased negativity along with increasing of tumor size. The positive PPD test had a tendency of positive correlation to the survival time and body mass index, however, inverse correlation with log (AFP), GOT and LDH was obserbed.
The survival rate in group of positive PPD tests more than 20mm skin reaction was significantly greater than that in those less than 20mm (p<0.001).
In patients with hypoalbuminemia, PPD and PHA tests showed lower reaction compared to the patients with normoalbuminemia.
Consequently it is suggested that PPD skin test is useful for prediction of prognosis in the patients with HCC.